GitDealFlowsignals

Q4 2025 Rankings

Healthcare Startups to Watch, Q4 2025

Healthcare tech engineering is picking up after a slow Q1, led by clinical workflow automation teams.

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Key takeaways, at a glance

In Q4 2025, 22 of 28 tracked healthcare startups show positive engineering acceleration. andes leads with 14 commits over 14 days (+1300% change). The dominant signal pattern is "Framework migration". Average sector commit velocity is 42 commits per 14-day window. These engineering momentum signals have historically preceded fundraise announcements by three to six weeks.

Data sourced from public GitHub activity. Read our methodology

Bar chart: Healthcare, Velocity Change. andes: +1300%, pharmaverse: +999%, epic-open-source: +999%, fedbiomed: +999%, metriport: +999%, simpledotorg: +700%, hpi-studyu: +520%, HCW-home: +300%.Healthcare, Velocity Changeandes+1300%pharmaverse+999%epic-open-source+999%fedbiomed+999%metriport+999%simpledotorg+700%hpi-studyu+520%HCW-home+300%
Healthcare, Velocity Change, top 8 startups by 14-day commit velocity change. Data: VC Deal Flow Signal.
Signal distribution for Healthcare: Framework migration (8), Deploy frequency spike (6), Engineering hiring burst (6), Deceleration (5), Infrastructure buildout (3). 28 startups total.28startups
Framework migration (8, 29%)
Deploy frequency spike (6, 21%)
Engineering hiring burst (6, 21%)
Deceleration (5, 18%)
Infrastructure buildout (3, 11%)
Signal type distribution across 28 healthcare startups. Data: VC Deal Flow Signal.
#CompanyStageCommits (14d)ChangeContributorsSignal
1andes

andes is ahealthcare series a/b startup, modernizing their technology stack for scale.

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Series A/B14+1300%44Deploy frequency spike
2pharmaverse

pharmaverse is ahealthcare growth startup based in EU, modernizing their technology stack for scale.

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Growth3+999%97Deploy frequency spike
3epic-open-source

Epic develops software to help people get well, help people stay well, and help future generations be healthier.

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Seed2+999%18Engineering hiring burst
4fedbiomed

Collaborative learning in heathcare

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Series A/B1+999%23Deploy frequency spike
5metriport

Metriport helps digital health companies access and manage health and medical data, through a universal open-source API.

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Growth5+999%62Engineering hiring burst
6simpledotorg

The fast, free app for clinicians to track patients with high blood pressure and diabetes.

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Series A/B8+700%37Deploy frequency spike
7hpi-studyu

hpi studyu is ahealthcare seed startup based in EU, rapidly expanding their engineering team.

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Seed31+520%17Engineering hiring burst
8HCW-home

Simple & Secure remote consultations

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Pre-seed8+300%6Deploy frequency spike
9HasteHealth

Digital health platform streamlining clinical documentation and patient engagement for healthcare providers.

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Pre-seed44+175%6Deploy frequency spike
10zapplyjobs

Free job boards and career resources for students & new grads

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Pre-seed66+136%7Framework migration
11ballerina-platform

ballerina platform is ahealthcare growth startup, investing in platform infrastructure and new product lines.

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Growth34+127%251Infrastructure buildout
12neuml

NeuML is the company behind txtai, one of the most popular open-source AI frameworks in the world.

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Series A/B9+125%26Framework migration
13tuva-health

The community building the future of healthcare analytics

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Series A/B15+114%48Infrastructure buildout
14healthchainai

Building developer tools and for the next generation of healthcare AI applications.

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Seed4+100%14Engineering hiring burst
15hapifhir

This is the source home for the HAPI FHIR project. Note that we are in the progress of migrating our codebase from the m

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Growth18+80%267Framework migration
16sunlabuiuc

sunlabuiuc is ahealthcare growth startup, modernizing their technology stack for scale.

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Growth11+57%56Framework migration
17Intelehealth

Open-source telemedicine platform connecting remote patients with healthcare providers in underserved regions.

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Seed243+53%14Infrastructure buildout
18earthians

earthians Health Informatics Pvt. Ltd.

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Growth3+50%86Engineering hiring burst
19ere-health

der virtuelle E-Rezept Drucker

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Series A/B3+50%30Framework migration
20medplum

Healthcare infrastructure

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Growth61+33%185Framework migration
21theislab

Theis Lab at Institute of Computational Biology, Helmholtz Munich

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Seed7+17%13Engineering hiring burst
22masslight

masslight is ahealthcare series a/b startup, modernizing their technology stack for scale.

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Series A/B474+7%28Framework migration
23insightsengineering

Roche/Genentech - Insights Engineering

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Series A/B2+0%27Framework migration
24samply

samply is ahealthcare series a/b startup, rapidly expanding their engineering team.

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Series A/B24-47%20Deceleration
25the-momentum

Building scalable, secure, and compliant healthtech solutions. We empower startups and scaleups to innovate and grow and

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Seed6-71%9Deceleration
26HeliosSoftware

Enterprise healthcare software providing practice management and electronic health record solutions.

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Seed42-71%14Deceleration
27ohcnetwork

Opensource Public Utility | Open Healthcare Network

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Growth45-79%330Deceleration
28third-culture-software

third culture software is ahealthcare series a/b startup, modernizing their technology stack for scale.

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Series A/B2-80%28Deceleration
Powered by VC Deal Flow Signal , real-time GitHub engineering data for investorsData from public GitHub API

Sorted by commit velocity change (14-day window, descending). Top 3 highlighted. Data last updated Q4 2025.

Browse the full Healthcare directory: all 28 startups, paginated
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Projected lead-time window

≈21-day lead window

Projected next milestone

Public launch / release

The free Sunday digest puts andes and 27 other Healthcare startups this period in context, 14-day acceleration deltas, contributor maps, and the top names not on Crunchbase yet. Five names every Sunday, no card, no code-reading.

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Projections are model estimates derived from each org's public commit signal and the SSRN-published methodology, not statements of fact. Cross-reference with primary sources before acting.

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Frequently Asked Questions

What engineering signals are healthcare startups showing in Q4 2025?

In Q4 2025, we are tracking 28 healthcare startups with measurable GitHub engineering signals. 22 of 28 show positive commit velocity growth. The most common signal type is "Framework migration", observed in 10 of the tracked companies. The average 14-day commit velocity across the sector is 42 commits, with andes leading at 14 commits (+1300% change). These patterns have historically preceded fundraise announcements by three to six weeks.

Which healthcare startup has the highest engineering acceleration in Q4 2025?

andes leads the healthcare sector in Q4 2025 with 14 commits over a 14-day window, representing a +1300% change from the prior period. With 44 active contributors, andes is showing a "Deploy frequency spike" pattern, one of the more reliable leading indicators of a significant product milestone or fundraise.

Where are the most active healthcare engineering teams located?

Among the 28 healthcare startups we track, EU accounts for the highest concentration with 6 teams. Startups applying technology to patient care, health systems, and drug discovery. Geographic distribution matters for investors because engineering talent clusters correlate with sector-specific domain expertise and proximity to early adopter customers.

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