Q4 2025 · United States
Healthcare Startups in United States to Watch, Q4 2025
5 healthcare startups based in United States ranked by GitHub engineering acceleration. Filtered from our broader Healthcare sector rankings.
| # | Company | Stage | Geo | Commits (14d) | Change | Contributors | Contrib. Growth | New Repos | Signal |
|---|---|---|---|---|---|---|---|---|---|
| 1 | metriport Metriport helps digital health companies access and manage health and medical data, through a universal open-source API. View signal profile → | Growth | US | 5 | +999% | 62 | +400% | 0 | Engineering hiring burst |
| 2 | zapplyjobs Free job boards and career resources for students & new grads View signal profile → | Pre-seed | US | 66 | +136% | 7 | +0% | 2 | Framework migration |
| 3 | tuva-health The community building the future of healthcare analytics View signal profile → | Series A/B | US | 15 | +114% | 48 | +0% | 3 | Infrastructure buildout |
| 4 | medplum Healthcare infrastructure View signal profile → | Growth | US | 61 | +33% | 185 | +0% | 2 | Framework migration |
| 5 | HeliosSoftware Enterprise healthcare software providing practice management and electronic health record solutions. View signal profile → | Seed | US | 42 | -71% | 14 | +0% | 0 | Deceleration |
Sorted by commit velocity change (14-day window, descending). Data last updated Q4 2025. Geography from GitHub org profiles.
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Frequently Asked Questions
Which healthcare startups in United States are showing the strongest engineering signals in Q4 2025?
In Q4 2025, metriport leads healthcare startups in United States with 5 commits over a 14-day window (+999% change) and 62 active contributors. Across all 5 tracked United States-based startups in this sector, the average 14-day commit velocity is 38 commits. The dominant signal pattern is "Framework migration", which typically indicates significant technical migration, which often precedes a pivot or platform upgrade.
How does the United States healthcare startup ecosystem compare to other regions?
United States accounts for 5 of the healthcare startups in our tracking dataset for Q4 2025. This geographic view filters the broader sector rankings to help investors focused on United States-based deal flow identify engineering acceleration patterns within their target geography. Regional concentrations often reflect local regulatory environments, talent pools, and investor networks that shape startup trajectories differently from global averages.
How is startup geography determined in these rankings?
We derive startup geography primarily from the GitHub organization profile location field, supplemented by a manually curated enrichment database of known startup headquarters. This means startups without a public GitHub location may appear in our global sector rankings but not in geographic filters. The geographic classification uses broad regions (United States, etc.) rather than city-level granularity to provide meaningful sample sizes for comparison.